药物血浆蛋白结合影响药效动力学体检查出艾滋被拒-甄选莫艺香港彩钢瓦翻新专用漆

药物血浆蛋白结合影响药效动力学体检查出艾滋被拒

更新时间：2026-01-22 10:14:56　|　人气：450939　|　作者：依彬雯,弘皓诚,　|

**药物血浆蛋白结合对药效动力学的影响**

**1. 引言**

药物在体内的作用不仅取决于其化学结构和药理活性，还受到药物动力学（Pharmacokinetics, PK）和药效动力学（Pharmacodynamics, PD）的调控。其中，药物与血浆蛋白的结合（Plasma Protein Binding, PPB）是影响药物分布、代谢和药效的关键因素之一。血浆蛋白（如白蛋白、α₁-酸性糖蛋白等）能够与药物分子结合，从而影响药物的游离浓度、组织分布、清除速率以及最终的药效学表现。本文将从血浆蛋白结合的基本概念出发，探讨其对药效动力学的影响，并分析其在临床用药中的意义。

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**2. 血浆蛋白结合的基本概念**

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药物血浆蛋白结合影响药效动力学体检查出艾滋被拒

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